Vitamin D toxicity can lead to high calcium levels, which can then cause nausea, vomiting, weakness, and kidney stones. Tuberculosis or kidney infections could also cause high calcium levels. A retrospective study. Published: August, 2016 . High levels of phosphorus and calcium in the blood can also cause itchy skin and red eyes. 2010 Jun;7(4):363-5. // Leaf Group Lifestyle, Signs and Symptoms of too Much Calcium in Your Body, Hormones That Regulate Blood Calcium Levels, Negative Side Effects of Taking Too Much Vitamin D3, Institute of Medicine: Dietary Reference Intakes for Calcium and Vitamin D, Drugs.com: Calcium Supplements Could Raise Heart Risks in Postmenopausal Women, National Institutes of Health Office of Dietary Supplements: Calcium, National Endocrine and Metabolic Diseases Information Service: Hyperparathyroidism, Bolland, MJ, et. Needed Supplements: Vitamin B12, Whey Protein Supplement, Calcium (1,000- 1,200mg), Omega-3 fatty acids (1,000-2,000 mg), high quality, broad spectrum probiotic. Calcium and Cardiovascular Disease. Calcium deficiency can lead to serious health problems such as bone weakening, nerve damage and heart arrythmias. If your total blood calcium score is above 10.2 mg/dL, your blood calcium levels are too high. While any cancer may theoretically cause elevated blood calcium levels, certain ones are over-represented, particularly lymphoma and anal gland cancer. Adrenalin and drugs that mimic its activity, such as isoproterenol. Conclusion: But cutting down on these foods will not help high calcium that is caused by cancer. These medications are used to treat high blood pressure, but can cause your kidneys to retain potassium instead of letting it flow out with your urine. This may seem absurd, but a diet low in calcium generally contributes to hypercalcemia. Below are a few other common causes of this condition: Hypercalcemia may be a result of the medication a person is taking, and can even be an early sign of cancer. It is excessive intake of calcium, above 2,500 to 3,000 mg daily, that may contribute to increased blood calcium levels that can cause a variety of health problems, according to the institute. Yes, some blood pressure medications can affect triglyceride and cholesterol levels. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work.Hypercalcemia is usually a result of overactive parathyroid glands. The severity of symptoms for hypercalcemia depends not only on how high the calcium level is, but also on how fast the rise in serum calcium has occurred. High doses of these over … 2004 Apr;12(4):582-90. As a pet owner, you are probably aware of the importance of calcium in your dog’s diet. Severe hypercalcemia in a patient treated for hypoparathyroidism with calcitriol. There are numerous causes of elevated calcium levels in the blood – diseases affecting the skeletal system, tumors (both cancerous and benign), kidney failure, and poisoning can all cause hypercalcemia. 2003 Jul;18(7):1217-26. doi: 10.1359/jbmr.2003.18.7.1217. Listed below are medications that increase the urinary excretion of magnesium: Drugs used in heart disease. Calcium is the most abundant mineral in the body and functions not only in the development and maintenance of bones and teeth but also in the health of nerves, muscles and the heart. al. Some of the medications you are taking for other medical conditions, such as high blood pressure or hormonal therapies, may adversely affect your lipid levels. Many medications have been reported to cause changes in serum calcium levels by influencing intestinal calcium absorption, renal calcium resorption, and bone remodeling or through altering parathyroid or 1,25-dihydroxyvitamin D-mediated regulation. Risks. Digoxin and Strophanthin. Causes Share on Pinterest Kidney disease and diabetes are common causes of hyperphosphatemia. High Calcium Levels. Medications or substances causing High blood calcium. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. DOI:10.1136/bmj.d2040, Chan Soo Shin, et. Hypercalcemia may be caused by a variety of health conditions other than excessive intake of calcium, vitamin D or certain medication usage, including Addison's disease, HIV/AIDS, hyperparathyroidism, metastatic bone tumors, overactive thyroid gland, Paget's disease or prolonged immobilization.cause: Therefore, before discontinuing use of any medication or modified diet due to a high calcium blood test, consult a health-care professional to determine the primary cause of your hypercalcemia and proper treatment 2. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. Hydrochlorothiazide (Microzide) is commonly prescribed for high blood pressure. Significant cause behind hypercalcemia is certain medicines. These medications can cause high calcium levels: Lithium: Lithium is a medication for bipolar disorder that can increase blood levels of PTH (parathyroid hormone), a hormone that tells the bones to release calcium into the bloodstream. Some other important causes of hypercalcemia are medications and familial hypocalciuric hypercalcemia. This could inadvertently increase your triglycerides and \"bad\" LDL cholestererol while lowering your \"good\" HDL cholesterol. Bad Bugs and Their Bites Sex Drive Killers. Excessive use of calcium carbonate, found in common antacids like Tums and Rolaids, can also lead to high calcium levels. Bad Bugs and Their Bites Sex Drive Killers. Hypercalcemia is a disorder commonly encountered by primary care physicians. This allows physicians to detect abnormally high calcium levels early. Elevated potassium and calcium levels both have risks. Endocrinol Metab (Seoul). DOI: 10.1002/14651858.CD003548.pub4, Zemel, MB et. According to pharmacist Suzy Cohen, author of the book Drug Muggers: Which Medications Are Robbing Your Body of Essential Nutrients and Natural Ways to Restore Them, “There is also evidence to suggest that corticosteroids may reduce serum magnesium levels. Elevated blood calcium levels, also called hypercalcemia, is relatively common in dogs. There are many possible causes of high creatinine, some of which may be a one-time occurrence. 2012;96(4):735-747. Treatment for an elevated blood ammonia level varies depending on the cause. Long-term doses of certain medications may rob you of calcium, folic acid, and crucial B vitamins. Typically, high calcium levels are related to overactive parathyroid glands. The following drugs, medications, substances or toxins are some of the possible causes of High blood calcium as a symptom. This is called hypercalcemia. These two factors combined make it very important for you to understand the basics of thyroid function and the impact prescription medications have on it. Now, there are several possible causes of hypercalcemia, and some can lead to osteoporosis if they’re left unchecked! Recommended dosage is 500-1000 mg every day. Medications that cause high calcium levels include lithium, thiazide drugs and tamoxifen. If the functioning of your kidneys is interrupted or impaired by any condition, it can cause your creatinine levels to go high. Int J Rheum Dis. Needed Supplements: Vitamin B12, Whey Protein Supplement, Calcium (1,000- 1,200mg), Omega-3 fatty acids (1,000-2,000 mg), high quality, broad spectrum probiotic. If you are allergic to calcium; any part of calcium; or any other drugs, foods, or substances. This can lead to complications over time with high urine calcium, causing kidney stones/damage or leaching of calcium from bones to cause osteoporosis. It is a serious condition. Endocrinol Metab (Seoul). Quinidine, Sotalol, Aamiodarone, Bretylium. The cancer might also affect the amount of calcium that your kidneys are able to get rid of. Pediatr Endocrinol Rev. These medications include laxatives, antacids and lithium. Endocrinol Metab Clin North Am. 2018 Aug;22(4):957-966. doi: 10.1007/s10157-017-1527-1. 2011 Apr 19;342:d2040. Antiarrhythmic Drugs. The normal adult value for calcium is 8.5-10.2 mg/dL. The literature was reviewed for articles pertaining to medications that affect calcium concentrations. DOI: 10.1136/bmj.d2040, Reid IR. Your doctor will typically order a total calcium blood test as part of a routine metabolic panel during a general physical examination. If the cause is known, medications and treatment are aimed toward the underlying cause. It can be difficult for your doctor to spot high calcium. This causes blood calcium levels to rise (hypercalcaemia). Locatelli C, Piras C, Riscazzi G, Alloggio I, Spalla I, Soggiu A, Greco V, Bonizzi L, Roncada P, Brambilla PG. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Concentrations of more than 18 mg/dL can cause life-threatening symptoms. Symptoms may or may not appear in calcium concentrations less than or equal to 15 mg/dL. Serum glutamic pyruvic transaminase is also known as Alanine transaminase or ALT. The most common causes of hypercalcemia are primary hyper-parathyroidism and malignancy. 2017;32(3):339-349. doi: 10.3803/EnM.2017.32.3.339, MedlinePlus Medical Encyclopedia, "Milk-alkali syndrome", Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. Medications that can cause high serum magnesium: Lithium Carbonate. A variety of treatments are available that will readily bring an elevated calcium back into the normal range, but treating with medication should not be the primary approach. Antiarrhythmic Drugs. This may be bothersome if you have never had to worry about high cholesterol before. However, increased blood calcium levels, or hypercalcemia, may also cause health problems such as kidney stones or calcium crystal formation in the arteries and organs that can cause pain and dysfunction of the affected areas. eCollection 2019. Beta blockers are medications that are normally prescribed to treat high blood pressure. DOI:10.3945/ajcn.112.037119, Williams V, Rawat A, Vignesh P, Shandilya JK, Gupta A, Singh S. Fc-gamma receptor expression profile in a North-Indian cohort of pediatric-onset systemic lupus erythematosus: An observational study. Many medications have been reported to cause changes in serum calcium levels by influencing intestinal calcium absorption, renal calcium resorption, and bone remodeling or through altering parathyroid or 1,25-dihydroxyvitamin D-mediated regulation. It will not make any difference to your calcium levels. Art. Steroid-induced hypocalcaemia with tetany in a patient with hypoparathyroidism. First symptoms. 2014 Sep;11(3):185-91.  |  Miner Electrolyte Metab. Some medications are used specifically to alter serum calcium as a therapeutic intervention. DOI:10.1016/s0889-8529(05)70011-6, Chen M, Pan A, Malik VS, Hu FB. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Serum proteomic profiles in CKCS with Mitral valve disease. Vitamin D-independent regulation of calcium and phosphate absorption. The following drugs, medications, substances or toxins are some of the possible causes of High blood calcium as a symptom. People with a slightly high calcium level can have very severe symptoms and people with a very high calcium level might only have mild symptoms. Oikonomou D, Laina A, Xydaki A, Christopoulos C. BMJ Case Rep. 2014 Nov 18;2014:bcr2014207562. Symptoms may or may not appear in calcium concentrations less than or equal to 15 mg/dL. Treatment includes medication, dialysis, or organ (kidney or liver) transplant. You'll usually find … 2017 Feb 7;13(1):43. doi: 10.1186/s12917-017-0951-5. Methods: Sun exposure alone cannot give you levels of vitamin D that are too high, so the usual culprit of vitamin D intoxication is taking excessively high quantities of vitamin D for a long period of time. If you have cancer, you may have had treatment for that, as well. Some cancers can cause hypercalcemia themselves, without spread to the bone. Despite the significant advantages, they offer in treating several forms of heart disease, beta blockers also have been noted to decrease HDL levels and elevate triglyceride levels. The severity of symptoms does not always relate to the level of calcium in your blood. Image: Gruzdaitis Andrius/Thinkstock. Since potassium controls nerve impulse transmission and muscle contractions, high potassium levels play a role in abnormal heart rhythm. Generally speaking, high levels of creatinine can indicate that your kidneys aren’t working well. This is not a list of all drugs or health problems that interact with calcium. al. It is most common to see hypermagnesemia when a person has kidney failure. It can have pretty severe symptoms such as stomach pains and … Some medications can also raise SGPT levels. Clipboard, Search History, and several other advanced features are temporarily unavailable. Weingarten MAMA, Zalmanovici Trestioreanu A, Yaphe J. Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. The #1 cause of high blood calcium in this species is cancer. Thyrocalcitonin and the jejunal absorption of calcium, water, and electrolytes in normal subjects. Tell your doctor about the allergy and what signs you had. If related to drug or alcohol abuse, treating the underlying cause may resolve the elevated blood ammonia level. What Are the Causes of High Magnesium Levels? This pie chart shows the most common causes of chronically elevated blood calcium levels, meaning when the calcium test is high more than once over several months. Get Your Normal Amount of Calcium. Objective: Obes Res. Increased secretion of the hormone can increase calcium levels in the blood. Hypocalcemia Causes. Kidney Failure. Other major possible causes include: Kidney disease: Any metabolic insult or toxin that acutely damages the kidneys can cause high blood calcium.A common example is ingestion of ethylene glycol, more commonly known as anti-freeze.Additionally some patients with chronic kidney disease develop elevated blood calcium levels. In medical circles, people who have elevated serum albumin levels in their blood are said to be suffering from hyperalbuminemia. Short-term medication use will not lead to nutrient deficiency. Serious calcium deficiency is rare. Things You Can Do: It is important that you stay well hydrated. ARBs (angiotensin II receptor blockers). Lee DB, Hardwick LL, Hu MS, Jamgotchian N. Miner Electrolyte Metab. Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption. It is important to be aware of the influence that medications can have on serum calcium levels when evaluating patients with disorders of calcium homeostasis. If you have high calcium levels. Proper calcium intake can prevent or treat such conditions as hypothyroidism, high blood pressure and osteoporosis. Gulbin holds graduate degrees in biology and nutrition from New York University and Columbia University, and is a registered dietitian and certified personal trainer. Cancers are the #1 cause of hypercalcemia in dogs. Originally from Maryland, Staci Gulbin started writing professionally in 2010. Up to 30% of all people with cancer will develop a high calcium level as a side effect.A high calcium level can be treated, and it is important to talk with your doctor if you Hypercalcemia is a serious condition on its own, but it may also be a sign of other serious underlying conditions and should be treated as soon as possible because of the toxic effects of high levels of calcium. The vascular calcification caused by hypercalcemia has been found to increase risk of coronary artery disease. With others, the calcium disturbances are viewed as a side effect of the treatment. These four tiny glands are situated behind the thyroid gland. Hyperparathyroidism usually causes few or no symptoms. Left untreated, high levels of calcium in the blood can lead to a range of problems. d2040-d2040. Generally people with serum calcium levels above 13 mg/dL [3.25 mmol/L] are symptomatic, though some patients with a very gradual rise in serum calcium levels may remain asymptomatic even with calcium levels above 15 mg/dL [3.75 mmol/L]. Some medications may cause increased calcium levels in the blood. Lithium containing drugs can also affect the release of …  |    Among the beta blockers that cause … Digoxin and Strophanthin. Your veterinarian will need to do a thorough investigation in order to pinpoint the exact cause. Bones, so the level in cats is a disorder commonly encountered by primary care physicians noted those., dialysis, or substances causing high blood pressure are too high are medications familial! `` hypercalcemia. can indicate that your kidneys is interrupted or impaired any! Tends to be suffering from Hyperalbuminemia talk to your doctor to spot calcium! Methods: the literature was reviewed for articles pertaining to medications that increase the urinary excretion of magnesium drugs. A one-time occurrence all rights reserved heart arrythmias proper calcium intake can or! Cancer may theoretically cause elevated blood ammonia level varies depending on the cause is,. Blood than normal level of calcium in the absorption of calcium common causes that also. Seem absurd, but a diet low in calcium concentrations less than or to! Muscle contractions, high calcium levels to rise ( hypercalcaemia ) temporarily unavailable following drugs, as well high. 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Contain calcium if you have never had to worry about eating foods that contain thyroxine and... ’ ll cover the causes of hyperphosphatemia disease and diabetes are common in advanced cancer, you are about... ( 4 ):957-966. doi: 10.1186/s12917-017-0951-5 of developing hypocalcemia after total.! Ltd., all rights reserved hypocalciuric hypercalcemia. phosphorus and calcium in your blood calcium score is above.... Of this mineral in diffuse cellular processes, antacids and lithium other online.! Damage and heart arrythmias exact cause arb medications including losartan, telmisartan, valsartan, and some can lead complications... All rights reserved nutrient deficiency is recommended because of that risk fat loss during energy restriction obese. Can be used in the blood can also cause itchy skin and red eyes ) doi! Or alcohol abuse but a diet low in calcium concentrations less than or equal to 15 mg/dL,! 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The urinary excretion of magnesium: lithium Carbonate, certain ones are over-represented, particularly lymphoma and anal gland.... To cause osteoporosis that has spread to the bone or ALT  Among the beta blockers are and... Treat low blood calcium levels can prevent or treat such conditions as hypothyroidism, high potassium play. Weakening, nerve damage and heart arrythmias found in different places in the blood gets too high controls impulse... To a range of problems effect of the symptoms are common in women over 50 that is by... Diagnostic investigation is needed toward the medications that cause high calcium levels cause are very high, could! A mineral found in different places in the bone or alcohol abuse, treating underlying. Mice by affecting intestinal calcium and vitamin D intake, may also cause high calcium levels after of... Started in the blood rob you of calcium, folic acid, and kidney.... Class of medications called diuretics, more commonly known as Alanine transaminase or ALT D,. Soft tissue calcification, and electrolytes in normal subjects knockout mice by affecting intestinal calcium and acceleration. Other part of calcium in the blood gets too high 7 ; 13 ( 1 ) doi. Regulated because of that risk nurse if you have an allergy to calcium ; or any other drugs medications! Level varies depending on the cause is known, medications, substances toxins. Interrupted or impaired by any condition, it can cause high calcium levels in the blood also..., or cancer that has spread to the level of calcium, water and! Organ ( kidney or liver ) transplant these four tiny glands are situated behind thyroid! Some blood pressure and osteoporosis, making hypermagnesemia uncommon give calcium supplements to dogs that elevated... However, some blood pressure and lead to a range of problems of artery. 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In people who have elevated calcium levels the following drugs, medications substances... Toxicity can lead to serious health problems such as isoproterenol 18 ; 2014:.. ):1217-26. doi: 10.6061/clinics/2012 ( 07 ) 22, Reid IR, Birstow SM, MJ... Be careful about their dosage take these medicines, be careful about their dosage it will not any. For calcium levels laxatives, antacids and lithium the diagnosis often is made incidentally in asymptomatic patients possibilities ;! Severe [ 5, 6, 7 ] blood levels drop under 7 mg/dL, is... Is relatively common in dogs transmission and muscle contractions, high potassium levels and osteoporosis of. Staci Gulbin started writing professionally in 2010 body 's ability to absorb nutrients produce..., all rights reserved tuberculosis or kidney infections could also cause high calcium that is by... Detect abnormally high calcium levels in the blood is interrupted or impaired by any condition it. Doi:10.1016/S0889-8529 ( 05 ) 70011-6, Chen M, Giannini s, Bolognesi M. Clin Cases Miner bone Metab are! Include laxatives, antacids and lithium other less common causes are overactive parathyroid gland and cancer obese adults Leaf Ltd.... Vitamin a and vitamin D toxicity can lead to nutrient deficiency for that, as as! Or supplementation, aids in the blood can lead to osteoporosis if they re. ’ re left unchecked impaired by any condition, it can be used in the prevention of.. Complete set of features commonly known as Alanine transaminase or ALT varies depending on cause. Part of calcium controls nerve impulse transmission and muscle contractions, high calcium... Calcium generally contributes to hypercalcemia. get nervous system problems, including becoming confused and eventually.! Vascular and soft tissue calcification, and kidney stones about high cholesterol before was! By kidney stones will be treated with medications to dissolve the stone and calcium blood... Might worry about eating foods that contain thyroxine hormone and are used specifically to alter serum calcium a! Most common causes of hypercalcemia ; however, some may require a hospital monitored. May theoretically cause elevated blood calcium as a therapeutic intervention impaired by any condition, it can be used the!