MSDS/SDS Database Search | Il a été découvert et purifié par Péligot et Dumas en 1834. Identification Product Name trans-Cinnamic acid Cat No. In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. Biologically Active Compounds | Treatment with 5 mM Cinnamic acid results in 75-95% loss of invasiveness[1]. - Find MSDS or SDS, a COA, data sheets and more information. B. Molecular Weight 148.16 . [1]. Shanghai Jizhi Biochemical Technology Co., Ltd. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. IndiaMART > Industrial Chemicals & Supplies > Cinnamic Acid. Mise à jour : 1984-01-30. This page contains information on the chemical Cinnamic Acid including: 56 synonyms/identifiers. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. Stable. trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. 3.3). Synonyms: TRANS-CINNAMIC-D5 ACID. It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. SAFETY DATA SHEET Creation Date 26-Sep-2009 Revision Date 14-Feb-2020 Revision Number 2 1. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. Fabrication de produits organiques Hygiène et sécurité Apparence . cis-cinnamic acid: ChEBI ID CHEBI:35699: ChEBI ASCII Name cis-cinnamic acid: Definition The Z (cis) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. Beilstein/REAXYS Number 1905952 . Density: 1.185g/cm 3: Melting Point: 131-136℃ Boling Point: 264.999°C at 760 mmHg: Flash Point: 189.53°C: Solubility: 0.4 g/L (20℃) Vapor Presure: 0.005mmHg at 25°C: Refractive Index: 1.616: trans-Cinnamic acid - Risk and Safety. Cinnamic acid (CA) and ferulic acid (FA) are naturally occurring phenolic acids claimed to exert beneficial effects against disorders related to oxidative stress, including cancer. Cinnamic acid: a natural product with potential use in cancer intervention. Selling Leads | Chemical Database Cinnamic Acid Identifications. It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. NOEL for sensitization was determined at 2.5% and 0.5% for cinnamyl alcohol and cinnamal, respectively, while cinnamic acid is non‐sensitizing. Il est obtenu à partir de l'extrait de la cannelle, à laquelle son ester éthylique donne son odeur caractéristique, ou de certains arbustes balsamiques. Cinnamic acid. It exists as both a cis and a trans isomer, although the latter is more common. Molecular Formula C 9 H 8 O 2; Average mass 148.159 Da; Monoisotopic mass 148.052429 Da; ChemSpider ID 392447 Contact Seller Ask for best deal. It is a member of styrenes and a member of cinnamic acids. Environmental, Chemistry & Hazardous Materials News, Careers & Resources. At last,trans-Cinnamic acid… Liu L, et al. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Liu L, et al. serum. trans-Cinnamic acid is an antimicrobial activity, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1. Hazard Symbols: Xi - Irritant: Risk Codes: R36/37/38 - Irritating to eyes, respiratory system and skin. It exists as both a cis and a trans isomer, although the latter is more common. ChemSynthesis Chemical database. It has a role as a plant metabolite. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. It is a self-inhibitor produced by fungal spores to prevent germination. Cinnamic acid, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 200 mg, 1133933: Cinnamic acid, United States Pharmacopeia (USP) Reference Standard, 8.00235: Cinnamic acid, for synthesis, Sorry we cannot compare more than 4 products at a time. EnvironmentalChemistry.com. LD The alkali salts are sol in water. Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Viability is determined by Trypan-blue exclusion assay[1]. Int J Cancer. MDL number MFCD00004369. CAS Number: 621-82-9; FEMA Number: 2288; Synonyms/Related: (2E)-3-phenylprop … : A13538 CAS-No 140-10-3 Synonyms 3-Phenyl-2-propenoic acid; trans-3-Phenylacrylic acid Recommended Use Laboratory chemicals. Get Latest Price Request a quote. Mise à jour : 1986-11-10. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. trans-Cinnamic acid ≥99% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. Cinnamic acid; 2-Propenoic acid, 3-phenyl- (E)-; trans-3-Phenylacrylic acid; trans-beta-Carboxystyrene Chemical Name: trans-Cinnamic Acid Chemical Formula: C9-H8-O2 Contact Information: Sciencelab.com, Inc. 14025 Smith Rd. cinnamic acid per 100 ml. CAS 140-10-3, chemical formula C₆H₅CH=CHCOOH. PubChem Substance ID … Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. The alkali salts are sol in water. ACM352431482. trans-cinnamic acid: ChEBI ID CHEBI:35697: ChEBI ASCII Name trans-cinnamic acid: Definition The E (trans) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. Propriétés physiques . Solide cristallin, jaunâtre à odeur aromatique. check more Cinnamic acid price, Home | Propriétés physiques . Acide cinnamique Cinnamic acid for synthesis. This factor (15.8) mayvary for different spectrophotom-eters and should be determined individually for any given instrument. Product Classification | CAS Number : 621-82-9 : Molecular Formula : C9H8O2 : Molecular weight : 148.16 : EINECS : 205-398-1 : Melting point : 133 : Boiling Point : 300 : View Complete Details. Within 5 days of treatment with 5 mM Cinnamic acid, melanoma 1011 cells appear enlarged with a markedly increased cytoplasm-to-nuclear ratio and well organized cytoskeleton, developed long dendritic processes and became highly melanotic. Properties of Cinnamic Acid: Name: Cinnamic Acid: Other Names: Cinnamylic acid, Isocinnamic acid, Benzenepropenoic acid, trans-Cinnamic acid, Phenylacrylic acid, 3-Phenylacrylic acid: Appearance: White monoclinic crystals: Molecular Formula: C 9 H 8 O 2: Melting Point: 133 °C: Boiling Point: 300 °C: Density: 1.2475 g/cm 3: Molar Mass: 148.161 g.mol –1: Solubility in Water About Us | Disclaimer, Copyright © 2018 ChemSrc All Rights Reserved. Create: Cinnamic acid CAS 140-10-3. Freely sol in benzene, ether, acetone, glacial acetic acid, carbon disulfide, oils. Cinnamic acid - cas 140-10-3, synthesis, structure, density, melting point, boiling point. Cells are grown for 3 days at 37°C in the presence or absence of the drug, then detached with trypsin/EDTA and counted in a Coulter counter. Int J Cancer. Cinnamic acid; Utilisation et sources d'émission. Cinnamic acid (C 9 H 10 O 2-purity 99%) was obtained from Acros Organics (Thermo Fisher Scientific, NJ, USA), diluted in RPMI 1640 medium containing 0.1 g/L of L-glutamine, 2.2 g/L sodium bicarbonate, and 10 mL/L of nonessential amino acids, and supplemented with 10% heat-inactivated fetal calf serum. Solide cristallin, jaunâtre à odeur aromatique. Combustible. (E)-Cinnamic acid - chemical information, properties, structures, articles, patents and more chemical data. Linear Formula C 6 H 5 CH=CHCOOH . Customer Support; Technical Service; … trans-Cinnamic acid; Noms anglais : trans-Cinnamic acid; Utilisation et sources d'émission. The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. Briefly, 5 X104 cells are plated in each well of a 24-well plate, allowed to attach overnight, and treated with compounds (e.g., Cinnamic acid: 2.5, 5, 10, 20, 30 mM) the following day. L'acide cinnamique de formule C 6 H 5 –CH=CHCOOH est un acide organique qui se présente sous la forme d'une poudre blanche inodore, avec une faible solubilité dans l'eau. Articles of Cinnamic acid are included as well. 5 to 20 times more than for tumor cells. Houston, Texas 77396 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 Order Online: ScienceLab.com CHEMTREC (24HR Emergency … Get all suppliers and price by the below link: Reference only. Service & Support. Cinnamic acid: a natural product with potential use in cancer intervention. Enterprises. LD 50 (g/kg): 3.57 orally in … 1995 Jul 28;62(3):345-50. Mise à jour : 1986-11-10. You can also browse global suppliers,vendor,prices,Price,manufacturers of trans-Cinnamic acid(140-10-3). Service | Cinnamic acids play key roles in the formation of other more complex phenolic compounds. Incompatible with strong oxidizing agents. EC Number 205-398-1. A straight line relationship is obtained, which for our Beckman Model DUUltraviolet Spectro-photometer followed the equation: (density unknown-density blank) X15.8=mg. Growth rates are determined by cell counting. 1995 Jul 28;62(3):345-50. Display Name: trans-cinnamic acid EC Number: 205-398-1 EC Name: trans-cinnamic acid CAS Number: 140-10-3 Molecular formula: C9H8O2 IUPAC Name: (2E)-3-phenylprop-2-enoic acid It is found in Cinnamomum cassia. The cell lines used, established from human malignant tumors, are A549 (lung cancer); PC3(M), Du145, and LNCaP (prostate cancer); A172, U251 (glioblastoma); and SKMEL28, A375(M), 1011 (melanoma). One such malignancy that still remains a therapeutic challenge mainly due to its heterogeneity and inaccessibility to t … It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Cinnamic acid. A. Date s: Modify: 2020-10-10. Mise à jour : 1984-01-30. Home; Text Search; Structure Search ; About; GO. Articles of Cinnamic acid are included as well. Synthetic indigo and pharmaceuticals A. sobria, SY-AS1 properties, structures, articles, patents and more information acrylic bearing! Information, properties, structures, articles, patents and more information the! White crystalline compound that is slightly soluble in water, and cinnamic acid density soluble in many organic solvents dose-dependent loss invasive. Amination to phenylalanine by the below link: Reference only 75-95 % loss of [. - Irritant: Risk Codes: R36/37/38 - Irritating to eyes, system... 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